I AM GOLD:
Study period:Ongoing.
I AM GOLD: The Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) Study is a multi-cohort study whose goal is to;
Examine airway microbial communities (the lung microbiome) and inflammatory gene expression markers at the time of acute infection and during chronic stable disease that are associated with HIV-associated COPD and lung function decline in HIV and to perform integrative analyses of the airway microbiome, microbial and human transcriptome, metabolome and lung radiographic changes in HIV+ COPD.
Sub studies
- TB-MBLA: This a cross-sectional study with an aim to Investigate the diagnostic and treatment monitoring accuracy of the Molecular Bacterial Load Assay (MBLA)among TB presumptive adults in reference to conventional methods in detecting TB causative agents including sputum smear microscopy, GeneXpert and culture.
- BIOFIRE: A cross-sectional study aimed at evaluating diagnostic performance of Film Array Pneumonia panel test compared to conventional methods in detecting pneumonia causative agents and their antimicrobial susceptibility patterns on sputum samples from HIV+ patients.
