Pharmacokinetics of Antimalarial Medications in Ugandan Children
Study period: June 2007 to December 2008.
Brief description: This study investigated the pharmacology of artemether/lumefantrine and artesunate/amodiaquine in HIV un-infected children in Kampala, Uganda. The comparison to prior adult data suggests that LR exposure is lower in children and that AQ/DEAQ exposure is similar in children and adults. For the artemisinin drugs, differences between exposure in children and adults vary depending on which artemisinin is administered. PK distinctions between children and adults should be considered to optimize dosing strategies for these widely utilized ACT regimens. Collaborators: MU-UCSF Research Collaboration. Sponsored by: CFAR, Drug Research Unit.
