Victor Asua
Victor Asua is a dedicated PhD student pursuing his studies at the prestigious Institute for Tropical Medicine, Eberhard Karls University of Tübingen in Germany. With a strong passion for tackling the global issue of antimalarial drug resistance, Victor’s PhD thesis research focuses on the evolution of antimalarial drug resistance in Uganda, explicitly delving in to phenotype-genotype association studies.
The primary objectives of Victor’s research project are twofold. Firstly, he aims to meticulously track the spatiotemporal patterns of antimalarial drug resistance evolution, providing critical insights into its development and spread. Secondly, Victor seeks to assess population-level signatures of genomic evolution within drug-resistant parasite isolates, deciphering the genetic adaptability of these disease-causing organisms.
To achieve these ambitious goals, Victor’s PhD project harnesses the power of next-generation sequencing and cutting-edge computational approaches. By employing these innovative techniques, he aims to unravel the underlying mechanisms and evolutionary adaptations that drive antimalarial drug resistance.
Before commencing his PhD training, Victor earned his master’s degree in Immunology and Clinical Microbiology. His academic pursuits were generously supported by funding from the Fogarty International Centre training on Malaria research grants, administered by the esteemed Infectious Diseases Research Collaboration (IDRC). Victor’s exceptional grasp of immunology and clinical microbiology forms a solid foundation for his endeavors in the field of malaria research.
Notably, Victor has also distinguished himself as an early career co-investigator in the ICEMR-Uganda program, funded by the US-National Institute for Health. This program further showcases his commitment to contributing to the scientific community’s understanding of infectious diseases particularly malaria.
Victor Asua’s unwavering dedication, comprehensive knowledge, and innovative research methods make him a promising young scientist in the fight against antimalarial drug resistance. Through his influential work, he aspires to make significant contributions to the field of malaria research and ultimately enhance our ability to combat this widespread global health concern.
Monica Mbabazi
Monica Mbabazi is a highly accomplished individual with a solid academic background and expertise in the field of bioinformatics. She holds a Master’s degree in Science. She is currently pursuing her doctoral studies in bioinformatics, focusing on understanding the genetic diversity and transmission networks of P. falciparum in south western Uganda.
As a PhD student, Monica’s research interests lie in exploring the intricate genetic makeup of the malaria-causing parasite P. falciparum, particularly in the context of the transmission networks prevalent in the south western region of Uganda. Her work involves analysing large-scale genomic data, employing advanced computational techniques, and utilising bioinformatics tools to unravel valuable insights about the parasite’s diversity and transmission patterns.
Monica’s passion for understanding malaria and her dedication to exploring genetic variations with P. falciparum has led her to serve as a postdoctoral research fellow at the Infectious Diseases Research Collaboration (IDRC). In this role, she works closely with a multidisciplinary team, contributing her expertise to ongoing research projects on infectious diseases.
With her strong academic foundation, expertise in bioinformatics and commitment to combating malaria, Monica Mbabazi is making significant, contributions to the field of infectious diseases research. Her work not only sheds light on the genetic diversity and transmission networks of P. falciparum but also paves the way for improved strategies in malaria control and prevention.
Shahiid Kiyaga
Shahiid Kiyaga is a dedicated and passionate researcher in the field of bioinformatics, with a specialization in malaria genomics. He holds a Masters in Science degree and is currently pursuing his Ph.D. in Bioinformatics. With a keen interest in the intersection of biology, data analysis, and computational modelling, Shahiid has made significant contributions to the field through his work on machine learning-based modelling of malaria incidence.
As an IDRC Bioinformatics Research Fellow, Shahiid’s primary focus lies in studying the transmission patterns of malaria in high risk areas of Uganda. Utilizing his expertise in bioinformatics, he applies machine learning algorithms to large datasets to identify important factors contributing to malaria incidence. By developing computational models, he aims to predict and understand the spread of the disease and develop effective preventive measures.
Shahiid’s research not only encompasses the analysis of genetic information related to malaria, but it also incorporates various environmental and socio-economic factors that influence transmission rates. By integrating multi-dimensional data, he strives to create comprehensive models that can assist in the development of targeted interventions and strategies to combat malaria in Uganda.
His work demonstrated the fusion of cutting-edge bioinformatics techniques and epidemiology, bringing forth innovative solutions to address the global challenge of malaria. Shahiid’s determination and relentless pursuit of knowledge have been recognized by his peers and mentors, as he continues to make significant strides in his research field.
With a strong foundation in genetics and computational biology, Shahiid’s research has the potential to revolutionize the way malaria is understood and managed. Through the application of machine learning algorithms and bioinformatics tools, he aims to develop a comprehensive platform for predicting malaria outbreaks, assessing their severity, and designing efficient control measures.
Aside from his research endeavors, Shahiid is an avid advocate for interdisciplinary collaboration in the field of health sciences. He actively participates in conferences, workshops, and academic communities to foster knowledge exchange and promote innovative approaches in malaria research.
Shahiid Kiyaga’s impressive academic background, combined with his passion for bioinformatics and malaria research, positions him as a leading figure in the field. His contributions to the machine learning-based modelling of malaria incidence in high transmission regions of Uganda hold great promise in the fight against the devastating disease.
Katairo Thomas
Katairo Thomas is a dedicated and accomplished professional with a strong background in the field of epidemiology and biostatistics. He holds a Masters in Science and his currently pursuing a PhD in Epidemiology of Plasmodium falciparum drug resistance in Uganda, under the Infectious Diseases Research Collaboration (IDRC).
With a focus on clinical epidemiology and biostatistics, Thomas possesses a comprehensive understanding of the factors influencing the spread and development of diseases. His expertise lies in studying and analysing the transmission dynamics, genetic characteristics, and drug resistance of the P. falciparum parasite.
As a member of IDRC, Thomas has been actively involved in research and fieldwork related to the genomics of drug resistance in Uganda. He collaborates closely with other researchers, scientists, and medical professionals to investigate the underlying mechanisms of drug resistance and identify potential solutions for combating the disease.
Thomas’s work involves utilizing advanced statistical tools and techniques to analyse complex data sets and draw meaningful conclusions. He applies his knowledge of genomics and molecular biology to explore the factors contributing to the adaptation and survival of the P. falciparum parasite. His findings play a crucial role in shaping public health policies and interventions aimed at reducing the burden of malaria in Uganda and other affected regions.
Beyond his academic pursuits, Thomas also serves as a genomics trainee at IDRC. This role allows him to further expand his expertise in the area of genomics and apply cutting-edge technologies to study the genetic basis of drug resistance.
With his multidisciplinary background and commitment to advancing the field of epidemiology, Katairo Thomas is an invaluable asset to the IDRC research team. Through his research and training, he strives to make a significant impact in the fight against malaria and contribute to the overall improvement of global health.
Kisakye Diana Kabbale
Kisakye Diana Kabbale is a highly accomplished individual in the field of medical research and infectious diseases. With a Bachelor of Medicine and Bachelor of Surgery (MBChB) degree, as well as a Masters in Science, she has continually demonstrated her commitment to advancing knowledge and finding solution to complex medical challenges.
Currently, Kisakye Diana Kabbale holds the position of a research fellow at the Infectious Diseases Research Collaboration (IDRC). Her research focuses on the development of a deep amplicon sequencing panel for drug efficacy estimation and surveillance of drug resistance markers in East Africa initiative. This important study aims to improve treatment outcomes for infectious diseases prevalent in the region and combat the emergence of drug resistance.
With her expertise in the field of infectious diseases, Kisakye Dianna Kabbale plays a vital role in the research collaboration. Her commitment to exploring innovative techniques, such as deep amplicon sequencing, showcases her dedication to finding practical solutions in the fight against infectious diseases.
Kisakye Diana Kabbale’s deep understanding of medical research methodologies combined with her practical experience as a medical practitioner, makes her a valuable asset to the project. Her attention to detail and analytical skills allow her to accurately estimate drug efficacy and identify drug resistance markers, contributing to developing more targeted and practical treatment approaches.
Beyond her academic and professional achievements, Kisakye Diana Kabbale is also known for her exceptional organisational and leadership abilities. Her strong work ethic and commitment to collaboration ensure seamless coordination among team members, fostering a productive research environment.
As an emerging expert in her field, Kisakye Diana Kabbale is passionate about using her knowledge and skills to improve healthcare outcomes, particularly for vulnerable populations in East Africa. Her dedication to making a positive impact on public health is commendable, and she continues to push boundaries and pioneer new approaches in the field of infectious diseases research.
Kisakye Diana Kabbale is a highly qualified and motivated individual with a strong background in medical research and infectious diseases. Her expertise and contributions to developing a deep amplicon sequencing panel for drug efficacy estimation and surveillance of drug resistance markers in the East Africa project have the potential to significantly impact medical practices and improve patient outcomes in the region.
Stephen Tukwasibwe
Stephen Tukwasibwe, MSc, PhD, is a research scientific officer at the Infectious Diseases Research Collaboration (IDRC), Makerere University, and a lecturer in Biochemistry and Molecular Biology at Uganda Christian University. With expertise in malaria molecular epidemiology, Dr Tukwasibwe’s research focuses on understanding the evolution of antimalarial drug resistance in Uganda and neighbouring countries.
Dr Tukwasibwe is dedicated to generating data that informs malaria control and treatment policies, with the ultimate goal of working towards malaria elimination in areas with a high disease burden. He oversees the malaria genomics and immunology activities at IDRC, providing crucial data on antimalarial and diagnostic resistance in Uganda. He actively advocates for incorporating this data into the decision-making process by policymakers at the Ministry of Health.
One of his ongoing projects is the GloCal Health fellowship for the year 2023-2024. This project involves surveillance of malaria drug resistance in refugee children in Uganda. Given the challenges posed by conflicts in many areas of Africa, Uganda, with its large refugee population, presents a unique opportunity to study molecular markers of drug and diagnostic resistance in these populations.
Through this project, Dr Tukwasibwe and his team collect samples from children entering Uganda refugee camps adjacent to South Sudan and the Democratic Republic of Congo. They determine the prevalence of malaria parasitemia, genotype markers of drug and diagnostic resistance, and evaluate the genetic relatedness of imported and local parasites. The resulting data will be instrumental in guiding treatment in policies for arriving refugees and reducing the spread of resistance.
Dr Tukwasibwe has also completed projects like the “Malaria Drug and Diagnostic Resistance in Refugee Children in Uganda.” As the principal investigator, he utilised the funding from the Thrasher Early Career Award to investigate the prevalence of drug and diagnostic resistance markers in refugee children within Uganda.
His contributions to science are exemplary. Dr Tukwasibwe has published several studies on the molecular basis of antimalarial drug resistance, associations between parasite genetic polymorphisms and drug sensitivity, and the impact of drug resistance on parasite fitness. Additionally, he has explored the role of immune system genes in malaria severity, providing insights into the genetics underlying the body’s immune response to the disease.
Stephen Tukwasibwe’s research work has a significant impact on malaria control strategies and informs policy decisions in Uganda. With his dedication to translational research and expertise in malaria immunology and genomics, he continues to play a vital role in the fight against malaria in the region.
(a) Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG, Rosenthal PJ. Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis. 2014; 210:154-7. PMID: 24446524; PMCID: PMC4162000.
(b) Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR, Dorsey G, Nsobya SL, Greenhouse B, Rosenthal PJ. Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitemic children in Uganda. Malar J. 2017; 16:125. PMID: 28327148; PMCID: PMC5361791.
(c) Tumwebaze P, Tukwasibwe S, Taylor A, Conrad M, Ruhamyankaka E, Asua V, Walakira A, Nankabirwa J, Yeka A, Staedke SG, Greenhouse B, Nsobya SL, Kamya MR, Dorsey G, Rosenthal PJ. Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. J Infect Dis. 2017; 215:631-635. PMID: 28039354; PMCID: PMC5853976.
(d) Cuu G, Asua V, Tukwasibwe S, Nsobya SL, Nanteza A, Kimuda MP, Mpimbaza A, Rosenthal PJ. Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda. Antimicrob Agents Chemother. 2020;64: e00721-20. PMID: 32660999; PMCID: PMC7508615.
(a) Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ. Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol. 2017; 55:281-287. PMID: 28939159; PMCID: PMC5685907.
(b) Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V, Rosenthal PJ. Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. PLoS One. 2018;13: e0203229. PMID: 30222732; PMCID: PMC6141089.
(c) Tukwasibwe S, Nakimuli A, Traherne J, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jagannathan P, Rosenthal PJ, Cose S, Colucci F. Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria. Cell Mol Immunol. 2020; 17:799-806. PMID: 32541835; PMCID: PMC7294524.
(d) Tukwasibwe S, Traherne JA, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jiang W, Nankabirwa JI, Rek J, Arinaitwe E, Nsobya SL, Atuheirwe M, Frank M, Godwin A, Jagannathan P, Cose S, Kamya MR, Dorsey G, Rosenthal PJ, Colucci F, Nakimuli A. Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity. Malar J. 2021; 20:111. PMID: 33632228; PMCID: PMC7908804.
Complete list of published work: https://scholar.google.com/citations?hl=en&user=n2MStNgAAAAJ
