SEARCH-IPT
Study period:Ongoing.
The Simplified Isoniazid Preventive Therapy Strategy to Reduce TB Burden (SEARCH-IPT) is a cluster randomized trial designed to determine if a multi-component implementation intervention (SEARCH-IPT) that targets District Health Officers (DHOs) can increase Isoniazid Preventative Therapy (IPT) initiation and completion among HIV-infected persons, and decrease Tuberculosis (TB) incidence, as compared to country standard practices in Uganda.
Objectives
- Determine if the SEARCH-IPT intervention increases IPT initiation
- Evaluate the effect of the SEARCH-IPT intervention on IPT completion and TB incidence
- Evaluate for indirect effects of the SEARCH-IPT intervention on prescribing of IPT to child (≤14 years of age) household contacts of active TB cases, and HIV-infected children (12 months to 14 years of age)
- Evaluate the cost and cost-effectiveness of SEARCH-IPT
