TCC – Tororo Child Cohort: Interaction between HIV and malaria in African Children
Study period: August 2007 to March 2013.
The study was designed to; assess whether trimethoprim-sulfamethoxazole(TMP/SMX) prophylaxis is highly effective in preventing malaria in both HIV-infected and HIV-uninfected children, assess the effect of TMP/SMX prophylaxis on selection of malaria parasites containing mutations confering resistance to antifolate drugs,and compare the efficacy, safety and tolerability of artemether-lumefantrine(AL) and dihydroartemisinin-piperaquine(DP) for the treatment of uncomplicated falciparum malaria among HIV-infected and uninfected children. The study demonstrated that TMP/SMX prophylaxis reduced the incidence of malaria by 39% and there was no difference in prevalence of markers of antifolate resistance in children who were on TMP/SMX prophylaxis compared to those who were not and that both DP and AL were equally efficacious and safe for treatment of uncomplicated malaria.Collaborators: MU-UCSF Research Collaboration. Sponsored by: The Doris Duke Charitable Foundation, Center for Disease Control (CDC)
